Bone marrow command center

Hematopoiesis lineage atlas

Tap any progenitor or mature cell. Use filters to isolate myeloid, lymphoid, erythroid, megakaryocytic, granulocytic, and monocytic lines. Growth factors sit on the exact branch they drive.

Myeloid Lymphoid EPO TPO G-CSF / GM-CSF M-CSF / IL-3

Tip: sideways scroll the map on mobile — the right panel updates when you tap a cell.

Selected cell

Hematopoietic stem cell

Self-renewing CD34+ marrow stem cell. Early survival/proliferation signals include stem cell factor/c-KIT, FLT3 ligand, IL-3, GM-CSF, IL-6, and thrombopoietin support.

Branch logicHSC → multipotent progenitor → common myeloid progenitor or common lymphoid progenitor.

Exam pearlEPO commits erythroid survival; TPO drives megakaryocytes and also supports HSC maintenance.

Quick exam trap

Which factor is most lineage-specific for neutrophil production, and which one broadly pushes granulocyte + macrophage progenitors?

G-CSF is most neutrophil-lineage specific. GM-CSF expands granulocyte–macrophage progenitors and supports neutrophils, eosinophils, monocytes/macrophages, and dendritic cells.